A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females - Online First - Springer

• Yubei Huang,
• Xiaoliang Zhang,
• Weiqin Li,
• Fengju Song,
• Hongji Dai,
• Jing Wang,
• Ying Gao,
• Xueou Liu,
• Chuan Chen,
• Ye Yan,
• Yaogang Wang,
• Kexin Chen
• …show all 12hide

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Objective

To evaluate the association between induced abortion (IA) and breast cancer risk among Chinese females.

Methods

We searched three English databases (PubMed, ScienceDirect, and Wiley) and three Chinese databases (CNKI, WanFang, and VIP) for studies up to December 2012, supplemented by manual searches. Two reviewers independently conducted the literature searching, study selection, and data extraction and quality assessment of included studies. Random effects models were used to estimate the summary odds ratios (ORs) and the 95 % confidence intervals (CIs).

Results

A total of 36 articles (two cohort studies and 34 case–control studies) covering 14 provinces in China were included in this review. Compared to people without any history of IA, an increased risk of breast cancer was observed among females who had at least one IA (OR = 1.44, 95 % CI 1.29–1.59, I2 = 82.6 %, p