List of adverse effects of risperidone - Wikipedia, the free encyclopedia
List of adverse effects of risperidone:
Sources:[1][2][3]
Note: The percentages provided next to these adverse effects is the incidence of them according to DrugPoint.[1]
Common (≥1%)[edit]
- Rash (oral, adults, 1% to 4%; pediatrics, up to 11% ; IM, less than 4%)
- Hyperprolactinaemia (risperidone is probably the most notorious antipsychotic for causing hyperprolactinaemia via its potent blockade of D2 receptors expressed on the lactotrophic cells of the pituitary)[4] (oral, adults, less than 1%; pediatrics, 49% to 87% ; IM, less than 4%)
- Weight gain (causes less weight gain than clozapine, olanzapine and zotepine, around as much weight gain as quetiapine and more weight gain than amisulpride, aripiprazole, lurasidone, asenapine and ziprasidone)[4] (oral, adult, 8.7% to 20.9%; pediatric, 14% to 32.6% ; IM, adult, 8% to 10%)
- Constipation (oral, 8% to 21% ; IM, 5% to 7%)
- Diarrhoea (oral, 1% to 8% ; IM, less than 4%)
- Excessive Salivation (oral, 1% to 10% ; IM, 1% to 4%)
- Increased appetite (oral, adult, more than 5%; pediatric, 4% to 47% ; IM, 4%)
- Indigestion (oral, 2% to 10% ; IM, 6%)
- Nausea (oral, 4% to 16% ; IM, 3% to 4%)
- Vomiting (oral, 10% to 25% ; IM, less than 4%)
- Upper abdominal pain (oral, adult, more than 5%; pediatric, 13% to 16%)
- Xerostomia (oral, 4% to 15% ; IM, up to 7%)
- Akathisia (oral, up to 10% ; IM, 4% to 11%)
- Dizziness (oral, 4% to 16% ; IM, 3% to 11%)
- Dyspnoea
- Asthenia
- Agitation
- Urinary incontinence
- Arthralgia
- Myalgia
- Epistaxis
- Somnolence (oral, adult, 3% to 6%; pediatric, 8% to 29% )
- Sleep disturbances
- Dose-dependent extrapyramidal side effects such as dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6% ; IM, adult, less than 4%), tremor (oral, 2% to 12% ; IM, 3% to 24%) and Parkinsonism (oral, 6% to 28% ; IM, 8% to 15%)
- Blurred vision (oral, 1% to 7% ; IM, 2% to 3%)
- Anxiety (oral, up to 16% IM, less than 4%)
- Cough (oral, adults, 2%; pediatrics, 24% ; IM, 2% to 4%)
- Nasal congestion (oral, adult, 4% to 6%; pediatric, 13%)
- Nasopharyngitis (oral, adult, 3% to 4%; pediatric, 21%)
- Pain in the throat (oral, adult, more than 5%; pediatric, 3% to 10%)
- Upper respiratory tract infection (oral, 2% to 8% ; IM, 2% and 6%)
- Fatigue (oral, adult, 1% to 3%; pediatric, 18% to 42% ; IM, 3% to 9%)
- Generalised pains (IM, 1% to 4%)
- Gynecomastia[5]
- Galactorrhea[6]
- Prolonged QT interval
- Sudden cardiac death
- Syncope (oral, up to 1% ; IM, up to 2%)
- Diabetic ketoacidosis
- Hypothermia
- Pancreatitis
- Agranulocytosis
- Neutropenia
- Leukopenia
- Thrombocytopenia
- Thrombotic thrombocytopenic purpura
- Stroke (oral, less than 5% ; IM, less than 4%)
- Seizure (oral, 0.3% ; IM, 0.3%)
- Tardive dyskinesia (oral, less than 5% ; IM, less than 4%)
- Priapism
- Pulmonary Embolism
- Neuroleptic Malignant Syndrome (oral, adults, less than 1%; pediatrics, less than 5%)
- Anorexia
- Hypoaesthesia
- ECG
- Impaired concentration
- Sexual dysfunction
- Angioedema
- Intestinal obstruction
- Oedema
- Hyponatraemia
References[edit]