"I would take the complaints of the corporate community with a grain of salt," Obama said, arguing that his policies have been friendly to business. "They always complain about regulation. That's their job."
Obama has increasingly promoted populist economic measures such as raising the minimum wage to motivate Democratic voters ahead of critical November congressional elections, in which his Democrats face the prospect of losing control of the Senate.
"Oftentimes, you'll hear some hedge-fund manager say, 'Oh, he's just trying to stir class resentment'. No. Feel free to keep your house in the Hamptons and your corporate jet, etcetera. I'm not concerned about how you're living," Obama said.
Read MoreObama toRepublicans: 'Stop hatin' all the time'
"I am concerned about making sure that we have a system in which the ordinary person who is working hard and is being responsible can get ahead," he said.
Obama had a frosty relationship with business in his first term, famously telling an interviewer: "I did not run for office to be helping out a bunch of fat cat bankers on Wall Street."