Tocopheryl acetate - Wikipedia
Tocopheryl acetate, also known as vitamin E acetate, is a common vitamin supplement with the molecular formula C31H52O3 (for 'α' form). It is the ester of acetic acid and tocopherol (vitamin E). It is often used in dermatological products such as skin creams. Tocopheryl acetate is not oxidized and can penetrate through the skin to the living cells, where about 5% is converted to free tocopherol. Claims are made for beneficial antioxidant effects.[1] Tocopheryl acetate is used as an alternative to tocopherol itself because the phenolic hydroxyl group is blocked, providing a less acidic product with a longer shelf life. It is believed that the acetate is slowly hydrolyzed after it is absorbed into the skin, regenerating tocopherol and providing protection against the sun's ultraviolet rays.[2]
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| Names | |
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| IUPAC name
[(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl] acetate | |
| Other names
Tocopherol acetate | |
| Identifiers | |
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| ChemSpider | |
| ECHA InfoCard | 100.000.369 |
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| Properties | |
| C31H52O3 | |
| Molar mass | 472.743 g/mol |
| Hazards | |
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Except where otherwise noted, data are given for materials in their standard state(at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Although there is widespread use of tocopheryl acetate as a topical medication, with claims for improved wound healing and reduced scar tissue,[3] reviews have repeatedly concluded that there is insufficient evidence to support these claims.[4][5] There are reports of vitamin E-induced allergic contact dermatitis from use of vitamin-E derivatives such as tocopheryl linoleate and tocopherol acetate in skin care products. Incidence is low despite widespread use.[6]
New York State Department of Health announced Thursday that their lab tests found vitamin E acetate at “very high levels” in nearly all of the cannabis-containing vape liquids linked to recent vaping related lung disease outbreak.[7] Vitamin E acetate, or alpha-tocopherol acetate, which is a less acidic, more shelf-stable form of vitamin E are used as thinning agent in bootleg THC vape carts.
References Edit
- ^ Linus Pauling Institute Research Report: All About E at the Wayback Machine (archived 2015-02-23)
- ^ Beijersbergen van Henegouwen G, Junginger H, de Vries H (1995). "Hydrolysis of RRR-alpha-tocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo study with the rat)". J Photochem Photobiol B. 29 (1): 45–51. doi:10.1016/1011-1344(95)90251-1. PMID 7472802.
- ^ Panin G, Strumia R, Ursini F (2004). "Topical alpha-tocopherol acetate in the bulk phase: eight years of experience in skin treatment". Ann. N. Y. Acad. Sci. 1031: 443–447. Bibcode:2004NYASA1031..443P. doi:10.1196/annals.1331.069. PMID 15753192.
- ^ Sidgwick GP, McGeorge D, Bayat A (2015). "A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring". Arch. Dermatol. Res. 307 (6): 461–477. doi:10.1007/s00403-015-1572-0. PMC 4506744 . PMID 26044054.
- ^ Tanaydin V, Conings J, Malyar M, van der Hulst R, van der Lei B (2016). "The Role of Topical Vitamin E in Scar Management: A Systematic Review". Aesthet Surg J. 36 (8): 959–965. doi:10.1093/asj/sjw046. PMID 26977069.
- ^ Kosari P, Alikhan A, Sockolov M, Feldman SR (2010). "Vitamin E and allergic contact dermatitis". Dermatitis. 21 (3): 148–153. PMID 20487657.
- ^ Sun, Lena (September 7, 2019). "Contaminant found in marijuana vaping products linked to deadly lung illnesses, tests show". The Washington Post.