Spanish flu - Wikipedia

1918 pandemic of H1N1 influenza virus

Spanish flu
DiseaseInfluenza
Virus strainH1N1
LocationWorldwide
First outbreakunknown
First reportedUnited States
DateJanuary 1918 – December 1920
Confirmed cases500 million (estimate)

Deaths

17–50 million (estimate)

The Spanish flu (also known as the 1918 flu pandemic[2]) was an unusually deadly influenza pandemic.[3] Lasting from January 1918 to December 1920, it infected 500 million people – about a quarter of the world's population at the time. The death toll is estimated to have been anywhere from 17 million[4] to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in human history.[5][6]

To maintain morale, World War I censors minimized early reports of illness and mortality in Germany, the United Kingdom, France, and the United States.[7] Newspapers were free to report the epidemic's effects in neutral Spain, such as the grave illness of King Alfonso XIII, and these stories created a false impression of Spain as especially hard hit. This gave rise to the name Spanish flu. Historical and epidemiological data are inadequate to identify with certainty the pandemic's geographic origin, with varying views as to its location.

Most influenza outbreaks disproportionately kill the very young and the very old, with a higher survival rate for those in between, but the Spanish flu pandemic resulted in a higher than expected mortality rate for young adults.[11] Scientists offer several possible explanations for the high mortality rate of the 1918 influenza pandemic. Some analyses have shown the virus to be particularly deadly because it triggers a cytokine storm, which ravages the stronger immune system of young adults. In contrast, a 2007 analysis of medical journals from the period of the pandemic[13][14] found that the viral infection was no more aggressive than previous influenza strains. Instead, malnourishment, overcrowded medical camps and hospitals, and poor hygiene promoted bacterial superinfection. This superinfection killed most of the victims, typically after a somewhat prolonged death bed.[15][16]

The Spanish flu was the first of two pandemics caused by the H1N1 influenza virus; the second was the swine flu in 2009.[17]

History

Hypotheses about the source

United Kingdom

The major UK troop staging and hospital camp in Étaples in France has been theorized by researchers as being at the center of the Spanish flu. The research was published in 1999 by a British team, led by virologist John Oxford.[18] In late 1917, military pathologists reported the onset of a new disease with high mortality that they later recognized as the flu. The overcrowded camp and hospital was an ideal site for the spreading of a respiratory virus. The hospital treated thousands of victims of chemical attacks, and other casualties of war, and 100,000 soldiers passed through the camp every day. It also was home to a piggery, and poultry was regularly brought in for food supplies from surrounding villages. Oxford and his team postulated that a significant precursor virus, harbored in birds, mutated and then migrated to pigs kept near the front.[19][20]

A report published in 2016 in the Journal of the Chinese Medical Association found evidence that the 1918 virus had been circulating in the European armies for months and possibly years before the 1918 pandemic.[21]

United States

There have been statements that the epidemic originated in the United States. Historian Alfred W. Crosby stated in 2003 that the flu originated in Kansas, and popular author John M. Barry described a January 1918 outbreak in Haskell County, Kansas, as the point of origin in his 2004 article.

A 2018 study of tissue slides and medical reports led by evolutionary biology professor Michael Worobey found evidence against the disease originating from Kansas as those cases were milder and had fewer deaths compared to the situation in New York City in the same time period. The study did find evidence through phylogenetic analyses that the virus likely had a North American origin, though it was not conclusive. In addition, the haemagglutinin glycoproteins of the virus suggest that it was around far prior to 1918 and other studies suggest that the reassortment of the H1N1 virus likely occurred in or around 1915.[23]

China

One of the few regions of the world seemingly less affected by the 1918 flu pandemic was China, where there may have been a comparatively mild flu season in 1918 (although this is disputed due to lack of data during the Warlord Period of China, see Around the globe). Multiple studies have documented that there were relatively few deaths from the flu in China compared to other regions of the world.[24][25][26] This has led to speculation that the 1918 flu pandemic originated in China.[27][25][28][29] The relatively mild flu season and lower rates of flu mortality in China in 1918 may be explained due to the fact that the Chinese population had already possessed acquired immunity to the flu virus.[30][27][25]

In 1993, Claude Hannoun, the leading expert on the 1918 flu for the Pasteur Institute, asserted the former virus was likely to have come from China. It then mutated in the United States near Boston and from there spread to Brest, France, Europe's battlefields, Europe, and the world with Allied soldiers and sailors as the main disseminators.[31]

In 2014, historian Mark Humphries argued that the mobilization of 96,000 Chinese laborers to work behind the British and French lines might have been the source of the pandemic. Humphries, of the Memorial University of Newfoundland in St. John's, based his conclusions on newly unearthed records. He found archival evidence that a respiratory illness that struck northern China in November 1917 was identified a year later by Chinese health officials as identical to the Spanish flu.[33]

A report published in 2016 in the Journal of the Chinese Medical Association found no evidence that the 1918 virus was imported to Europe via Chinese and Southeast Asian soldiers and workers and instead found evidence of its circulation in Europe before the pandemic.[21] The 2016 study suggested that the low flu mortality rate (an estimated 1/1000) found among the Chinese and Southeast Asian workers in Europe meant that the deadly 1918 influenza pandemic could not have originated from those workers.[21]

A 2018 study of tissue slides and medical reports led by evolutionary biology professor Michael Worobey found evidence against the disease being spread by Chinese workers, noting that workers entered Europe through other routes that did not result in detectable spread, making them unlikely to have been the original hosts.[23]

Other

Hannoun considered several alternative hypotheses of origin, such as Spain, Kansas, and Brest, as being possible, but not likely.[31] Political scientist Andrew Price-Smith published data from the Austrian archives suggesting the influenza began in Austria in early 1917.

Spread

As U.S. troops deployed en masse for the

war effort in Europe

, they carried the Spanish flu with them.

When an infected person sneezes or coughs, more than half a million virus particles can spread to those nearby.[35] The close quarters and massive troop movements of World War I hastened the pandemic, and probably both increased transmission and augmented mutation. The war may also have increased the lethality of the virus. Some speculate the soldiers' immune systems were weakened by malnourishment, as well as the stresses of combat and chemical attacks, increasing their susceptibility.

A large factor in the worldwide occurrence of this flu was increased travel. Modern transportation systems made it easier for soldiers, sailors, and civilian travelers to spread the disease.[38] Another was lies and denial by governments, leaving the population ill-prepared to handle the outbreaks.[39]

In the United States, the disease was first observed in Haskell County, Kansas, in January 1918, prompting local doctor Loring Miner to warn the US Public Health Service's academic journal. On 4 March 1918, company cook Albert Gitchell, from Haskell County, reported sick at Fort Riley, a US military facility that at the time was training American troops during World War I, making him the first recorded victim of the flu.[40][41][42] Within days, 522 men at the camp had reported sick.[43] By 11 March 1918, the virus had reached Queens, New York.[38] Failure to take preventive measures in March/April was later criticised.

In August 1918, a more virulent strain appeared simultaneously in Brest, France; in Freetown, Sierra Leone; and in the U.S., in September, at the Boston Navy Yard and Camp Devens (later renamed Fort Devens), about 30 miles west of Boston. Other U.S. military sites were soon afflicted, as were troops being transported to Europe.[45] The Spanish flu also spread through Ireland, carried there by returning Irish soldiers.[citation needed ] The Allies of World War I came to call it the Spanish flu, primarily because the pandemic received greater press attention after it moved from France to Spain in November 1918. Spain was not involved in the war and had not imposed wartime censorship.[46]

Mortality

Around the globe

The difference between the influenza mortality age-distributions of the 1918 epidemic and normal epidemics – deaths per 100,000 persons in each age group, United States, for the interpandemic years 1911–1917 (dashed line) and the pandemic year 1918 (solid line)

Three pandemic waves: weekly combined influenza and pneumonia mortality, United Kingdom, 1918–1919

Estimates vary as to the total number who died. An estimate from 1991 says it killed 25–39 million people. A 2005 estimate put the death toll at probably 50 million (less than 3% of the global population), and possibly as high as 100 million (more than 5%). However, a reassessment in 2018 estimated the total to be about 17 million,[4] though this has been contested.[52] With a world population of 1.8 to 1.9 billion,[53] these estimates correspond to between 1 and 6 percent of the population.

This flu killed more people in 24 weeks than HIV/AIDS killed in 24 years. The Black Death, which lasted much longer, killed a much higher percentage of the world's then smaller population.[55]

The disease killed in many parts of the world. Some 12-17 million people died in India, about 5% of the population.[56] The death toll in India's British-ruled districts was 13.88 million.[57] Arnold (2019) estimates at least 12 million dead.[58]

Estimates for the death toll in China have varied widely,[59] a range which reflects the lack of centralised collection of health data at the time due to the Warlord period. The first estimate of the Chinese death toll was made in 1991 by Patterson and Pyle, which estimated China had a death toll of between 5 and 9 million. However, this 1991 study was later criticized by later studies due to flawed methodology, and newer studies have published estimates of a far lower mortality rate in China.[24][60][61] For instance, Iijima in 1998 estimates the death toll in China to be between 1 and 1.28 million based on data available from Chinese port-cities.[62] As Wataru Iijima notes,

"Patterson and Pyle in their study 'The 1918 Influenza Pandemic' tried to estimate the number of deaths by Spanish influenza in China as a whole. They argued that between 4.0 and 9.5 million people died in China, but this total was based purely on the assumption that the death rate there was 1.0–2.25 per cent in 1918, because China was a poor country similar to Indonesia and India where the mortality rate was of that order. Clearly their study was not based on any local Chinese statistical data."[63]

The lower estimates of the Chinese death toll are based on the low mortality rates that were found in Chinese port-cities (for example, Hong Kong) and on the assumption that poor communications prevented the flu from penetrating the interior of China.[59] However, some contemporary newspaper and post office reports, as well as reports from missionary doctors, suggest that the flu did penetrate the Chinese interior and that influenza was bad in some locations in the countryside of China.[64]

In Japan, 23 million people were affected, with at least 390,000 reported deaths.[65] In the Dutch East Indies (now Indonesia), 1.5 million were assumed to have died among 30 million inhabitants.[66] In Tahiti, 13% of the population died during one month. Similarly, in Samoa 22% of the population of 38,000 died within two months.

In New Zealand, the flu killed an estimated 6,400 Pakeha and 2,500 indigenous Maori in six weeks, with Māori dying at eight times the rate of Pakeha.[68][69]

In Iran, the mortality was very high: according to an estimate, between 902,400 and 2,431,000, or 8% to 22% of the total population died.

In the U.S., about 28% of the population of 105 million became infected, and 500,000 to 675,000 died (0.48 to 0.64 percent of the population).[71] Native American tribes were particularly hard hit. In the Four Corners area, there were 3,293 registered deaths among Native Americans.[72] Entire Inuit and Alaskan Native village communities died in Alaska.[73] In Canada, 50,000 died.[74]

In Brazil, 300,000 died, including president Rodrigues Alves.[75] In Britain, as many as 250,000 died; in France, more than 400,000.[76]

In Ghana, the influenza epidemic killed at least 100,000 people. Tafari Makonnen (the future Haile Selassie, Emperor of Ethiopia) was one of the first Ethiopians who contracted influenza but survived.[78] Many of his subjects did not; estimates for fatalities in the capital city, Addis Ababa, range from 5,000 to 10,000, or higher. In British Somaliland, one official estimated that 7% of the native population died.

This huge death toll resulted from an extremely high infection rate of up to 50% and the extreme severity of the symptoms, suspected to be caused by cytokine storms. Symptoms in 1918 were unusual, initially causing influenza to be misdiagnosed as dengue, cholera, or typhoid. One observer wrote, "One of the most striking of the complications was hemorrhage from mucous membranes, especially from the nose, stomach, and intestine. Bleeding from the ears and petechial hemorrhages in the skin also occurred". The majority of deaths were from bacterial pneumonia,[82][83] a common secondary infection associated with influenza. The virus also killed people directly by causing massive hemorrhages and edema in the lungs.

Patterns of fatality

The pandemic mostly killed young adults. In 1918–1919, 99% of pandemic influenza deaths in the U.S. occurred in people under 65, and nearly half of deaths were in young adults 20 to 40 years old. In 1920, the mortality rate among people under 65 had decreased sixfold to half the mortality rate of people over 65, but 92% of deaths still occurred in people under 65. This is unusual, since influenza is typically most deadly to weak individuals, such as infants under age two, adults over age 70, and the immunocompromised. In 1918, older adults may have had partial protection caused by exposure to the 1889–1890 flu pandemic, known as the "Russian flu".[86]

According to historian John M. Barry, the most vulnerable of all – "those most likely, of the most likely", to die – were pregnant women. He reported that in thirteen studies of hospitalized women in the pandemic, the death rate ranged from 23% to 71%.[87] Of the pregnant women who survived childbirth, over one-quarter (26%) lost the child.

Another oddity was that the outbreak was widespread in the summer and autumn (in the Northern Hemisphere); influenza is usually worse in winter.[89]

Alberta

's provincial board of health poster

Modern analysis has shown the virus to be particularly deadly because it triggers a cytokine storm (overreaction of the body's immune system), which ravages the stronger immune system of young adults. One group of researchers recovered the virus from the bodies of frozen victims and transfected animals with it. The animals suffered rapidly progressive respiratory failure and death through a cytokine storm. The strong immune reactions of young adults were postulated to have ravaged the body, whereas the weaker immune reactions of children and middle-aged adults resulted in fewer deaths among those groups.[90]

In fast-progressing cases, mortality was primarily from pneumonia, by virus-induced lung consolidation. Slower-progressing cases featured secondary bacterial pneumonia, and possibly neural involvement that led to mental disorders in some cases. Some deaths resulted from malnourishment.

A study conducted by He et al. (2011) used a mechanistic modeling approach to study the three waves of the 1918 influenza pandemic. They examined the factors that underlie variability in temporal patterns and their correlation to patterns of mortality and morbidity. Their analysis suggests that temporal variations in transmission rate provide the best explanation, and the variation in transmission required to generate these three waves is within biologically plausible values.

Another study by He et al. (2013) used a simple epidemic model incorporating three factors to infer the cause of the three waves of the 1918 influenza pandemic. These factors were school opening and closing, temperature changes throughout the outbreak, and human behavioral changes in response to the outbreak. Their modeling results showed that all three factors are important, but human behavioral responses showed the most significant effects.

Deadly second wave

The second wave of the 1918 pandemic was much deadlier than the first. The first wave had resembled typical flu epidemics; those most at risk were the sick and elderly, while younger, healthier people recovered easily. By August, when the second wave began in France, Sierra Leone, and the United States,[93] the virus had mutated to a much deadlier form. October 1918 was the deadliest month of the whole pandemic.[94]

This increased severity has been attributed to the circumstances of the First World War. In civilian life, natural selection favors a mild strain. Those who get very ill stay home, and those mildly ill continue with their lives, preferentially spreading the mild strain. In the trenches, natural selection was reversed. Soldiers with a mild strain stayed where they were, while the severely ill were sent on crowded trains to crowded field hospitals, spreading the deadlier virus. The second wave began, and the flu quickly spread around the world again. Consequently, during modern pandemics, health officials pay attention when the virus reaches places with social upheaval (looking for deadlier strains of the virus).

The fact that most of those who recovered from first-wave infections had become immune showed that it must have been the same strain of flu. This was most dramatically illustrated in Copenhagen, which escaped with a combined mortality rate of just 0.29% (0.02% in the first wave and 0.27% in the second wave) because of exposure to the less-lethal first wave.[97] For the rest of the population, the second wave was far more deadly; the most vulnerable people were those like the soldiers in the trenches – adults who were young and fit.

Devastated communities

A chart of deaths from all causes in major cities, showing a peak in October and November 1918

Coromandel Hospital Board (

New Zealand

) advice to influenza sufferers (1918)

Even in areas where mortality was low, so many adults were incapacitated that much of everyday life was hampered. Some communities closed all stores or required customers to leave orders outside. There were reports that healthcare workers could not tend the sick nor the gravediggers bury the dead because they too were ill. Mass graves were dug by steam shovel and bodies buried without coffins in many places.[99]

Several Pacific island territories were hit particularly hard. The pandemic reached them from New Zealand, which was too slow to implement measures to prevent ships, such as the SS Talune, carrying the flu from leaving its ports. From New Zealand, the flu reached Tonga (killing 8% of the population), Nauru (16%), and Fiji (5%, 9,000 people).

Worst affected was Western Samoa, formerly German Samoa, which had been occupied by New Zealand in 1914. 90% of the population was infected; 30% of adult men, 22% of adult women, and 10% of children died. By contrast, Governor John Martin Poyer prevented the flu from reaching neighboring American Samoa by imposing a blockade. The disease spread fastest through the higher social classes among the indigenous peoples, because of the custom of gathering oral tradition from chiefs on their deathbeds; many community elders were infected through this process.[101]

In New Zealand, 8,573 deaths were attributed to the 1918 pandemic influenza, resulting in a total population fatality rate of 0.7%. Māori were 8 to 10 times as likely to die as Pakeha, because of their relative poverty, more crowded housing, rural population and lesser immunity to disease.[101]

In Ireland, the Spanish flu accounted for 10% of the total deaths in 1918.[citation needed ]

Less-affected areas

China may have experienced a relatively mild flu season in 1918 compared to other areas of the world.[103][104][30][105] However, there was no centralised collection of health statistics in the country at the time, and some reports from its interior suggest that mortality rates from influenza were perhaps higher in at least a few locations in China in 1918.[64] However, at the very least, there is little evidence that China as a whole was seriously affected by the flu compared to other countries in the world.[106] Although medical records from China's interior are lacking, there was extensive medical data recorded in Chinese port-cities, such as then British-controlled Hong Kong, Canton, Peking, Harbin and Shanghai. This data was collected by the Chinese Maritime Customs Service, which was largely staffed by non-Chinese foreigners, such as the British, French, and other European colonial officials in China.[107] As a whole, accurate data from China's port cities show astonishingly low mortality rates compared to other cities in Asia.[107] For example, the British authorities at Hong Kong and Canton reported a mortality rate from influenza at a rate of 0.25% and 0.32%, much lower than the reported mortality rate of other cities in Asia, such as Calcutta or Bombay, where influenza was much more devastating.[107][108] Similarly, in the city of Shanghai – which had a population of over 2 million in 1918 – there were only 266 recorded deaths from influenza among the Chinese population in 1918.[107] If extrapolated from the extensive data recorded from Chinese cities, the suggested mortality rate from influenza in China as a whole in 1918 was likely lower than 1% – much lower than the world average (which was around 3–5%).[107] In contrast, Japan and Taiwan had reported a mortality rate from influenza around 0.45% and 0.69% respectively, higher than the mortality rate collected from data in Chinese port cities, such as Hong Kong (0.25%), Canton (0.32%), and Shanghai.[107]

In Japan, 257,363 deaths were attributed to influenza by July 1919, giving an estimated 0.4% mortality rate, much lower than nearly all other Asian countries for which data are available. The Japanese government severely restricted sea travel to and from the home islands when the pandemic struck.

In the Pacific, American Samoa[109] and the French colony of New Caledonia[110] also succeeded in preventing even a single death from influenza through effective quarantines. In Australia, nearly 12,000 perished.[111]

By the end of the pandemic, the isolated island of Marajó, in Brazil's Amazon River Delta had not reported an outbreak.[112] Saint Helena also reported no deaths.[113]

The death toll in Russia has been estimated at 450,000, though the epidemiologists who suggested this number called it a "shot in the dark". If it is correct, Russia lost roughly 0.4% of its population, meaning it suffered the lowest influenza-related mortality in Europe. Another study considers this number unlikely, given that the country was in the grip of a civil war, and the infrastructure of daily life had broken down; the study suggests that Russia's death toll was closer to 2%, or 2.7 million people.[64]

Aspirin poisoning

In a 2009 paper published in the journal Clinical Infectious Diseases, Karen Starko proposed that aspirin poisoning contributed substantially to the fatalities. She based this on the reported symptoms in those dying from the flu, as reported in the post mortem reports still available, and also the timing of the big "death spike" in October 1918. This occurred shortly after the Surgeon General of the U.S. Army and the Journal of the American Medical Association both recommended very large doses of 8 to 31 grams of aspirin per day as part of treatment. These levels will produce hyperventilation in 33% of patients, as well as lung edema in 3% of patients.

Starko also notes that many early deaths showed "wet", sometimes hemorrhagic lungs, whereas late deaths showed bacterial pneumonia. She suggests that the wave of aspirin poisonings was due to a "perfect storm" of events: Bayer's patent on aspirin expired, so many companies rushed in to make a profit and greatly increased the supply; this coincided with the Spanish flu; and the symptoms of aspirin poisoning were not known at the time.

A street car conductor in

Seattle

in 1918 refusing to allow passengers aboard who are not wearing masks

As an explanation for the universally high mortality rate, this hypothesis was questioned in a letter to the journal published in April 2010 by Andrew Noymer and Daisy Carreon of the University of California, Irvine, and Niall Johnson of the Australian Commission on Safety and Quality in Health Care. They questioned the universal applicability of the aspirin theory, given the high mortality rate in countries such as India, where there was little or no access to aspirin at the time, compared to the death rate in places where aspirin was plentiful.

They concluded that "the salicylate [aspirin] poisoning hypothesis [was] difficult to sustain as the primary explanation for the unusual virulence of the 1918–1919 influenza pandemic". In response, Starko said there was anecdotal evidence of aspirin use in India and argued that even if aspirin over-prescription had not contributed to the high Indian mortality rate, it could still have been a factor for high rates in areas where other exacerbating factors present in India played less of a role.

End of the pandemic

After the lethal second wave struck in late 1918, new cases dropped abruptly – almost to nothing after the peak in the second wave. In Philadelphia, for example, 4,597 people died in the week ending 16 October, but by 11 November, influenza had almost disappeared from the city. One explanation for the rapid decline in the lethality of the disease is that doctors became more effective in prevention and treatment of the pneumonia that developed after the victims had contracted the virus. However, John Barry stated in his 2004 book The Great Influenza: The Epic Story of the Deadliest Plague In History that researchers have found no evidence to support this position. Some fatal cases did continue into March 1919, killing one player in the 1919 Stanley Cup Finals.

Another theory holds that the 1918 virus mutated extremely rapidly to a less lethal strain. This is a common occurrence with influenza viruses: there is a tendency for pathogenic viruses to become less lethal with time, as the hosts of more dangerous strains tend to die out (see also "Deadly Second Wave", above).

Long-term effects

A 2006 study in the Journal of Political Economy found that "cohorts in utero during the pandemic displayed reduced educational attainment, increased rates of physical disability, lower income, lower socioeconomic status, and higher transfer payments received compared with other birth cohorts."[117] A 2018 study found that the pandemic reduced educational attainment in populations.[118]

The flu has been linked to the outbreak of encephalitis lethargica in the 1920s.

Legacy

Academic Andrew Price-Smith has made the argument that the virus helped tip the balance of power in the latter days of the war towards the Allied cause. He provides data that the viral waves hit the Central Powers before the Allied powers and that both morbidity and mortality in Germany and Austria were considerably higher than in Britain and France.

Despite the high morbidity and mortality rates that resulted from the epidemic, the Spanish flu began to fade from public awareness over the decades until the arrival of news about bird flu and other pandemics in the 1990s and 2000s. This has led some historians to label the Spanish flu a "forgotten pandemic".

There are various theories of why the Spanish flu was "forgotten". The rapid pace of the pandemic, which, for example, killed most of its victims in the United States within less than nine months, resulted in limited media coverage. The general population was familiar with patterns of pandemic disease in the late 19th and early 20th centuries: typhoid, yellow fever, diphtheria and cholera all occurred near the same time. These outbreaks probably lessened the significance of the influenza pandemic for the public. In some areas, the flu was not reported on, the only mention being that of advertisements for medicines claiming to cure it.

Additionally, the outbreak coincided with the deaths and media focus on the First World War. Another explanation involves the age group affected by the disease. The majority of fatalities, from both the war and the epidemic, were among young adults. The number of war-related deaths of young adults may have overshadowed the deaths caused by flu.

When people read the obituaries, they saw the war or postwar deaths and the deaths from the influenza side by side. Particularly in Europe, where the war's toll was high, the flu may not have had a tremendous psychological impact or may have seemed an extension of the war's tragedies. The duration of the pandemic and the war could have also played a role. The disease would usually only affect a particular area for a month before leaving. The war, however, had initially been expected to end quickly but lasted for four years by the time the pandemic struck.

1918 influenza epidemic burial site in

Auckland

, New Zealand

Regarding global economic effects, many businesses in the entertainment and service industries suffered losses in revenue, while the healthcare industry reported profit gains. Historian Nancy Bristow has argued that the pandemic, when combined with the increasing number of women attending college, contributed to the success of women in the field of nursing. This was due in part to the failure of medical doctors, who were predominantly men, to contain and prevent the illness. Nursing staff, who were mainly women, celebrated the success of their patient care and did not associate the spread of the disease with their work.[125]

In Spain, sources from the period explicitly linked the Spanish flu to the cultural figure of Don Juan. The nickname for the flu, the "Naples Soldier", was adopted from Federico Romero and Guillermo Fernández Shaw's 1916 operetta, The Song of Forgetting (La canción del olvido). The protagonist of the operetta was a stock Don Juan type. Federico Romero, one of the librettists, quipped that the play's most popular musical number, Naples Soldier, was as catchy as the flu. Davis argued the Spanish flu–Don Juan connection allowed Spaniards to make sense of their epidemic experience by interpreting it through their familiar Don Juan story.

Research

An electron micrograph showing recreated 1918 influenza virions

The origin of the Spanish flu pandemic, and the relationship between the near-simultaneous outbreaks in humans and swine, have been controversial. One hypothesis is that the virus strain originated at Fort Riley, Kansas, in viruses in poultry and swine which the fort bred for food; the soldiers were then sent from Fort Riley around the world, where they spread the disease.[127] Similarities between a reconstruction of the virus and avian viruses, combined with the human pandemic preceding the first reports of influenza in swine, led researchers to conclude the influenza virus jumped directly from birds to humans, and swine caught the disease from humans.[128]

Others have disagreed, and more recent research has suggested the strain may have originated in a nonhuman, mammalian species. An estimated date for its appearance in mammalian hosts has been put at the period 1882–1913. This ancestor virus diverged about 1913–1915 into two clades (or biological groups), which gave rise to the classical swine and human H1N1 influenza lineages. The last common ancestor of human strains dates to between February 1917 and April 1918. Because pigs are more readily infected with avian influenza viruses than are humans, they were suggested as the original recipients of the virus, passing the virus to humans sometime between 1913 and 1918.

An effort to recreate the 1918 flu strain (a subtype of avian strain H1N1) was a collaboration among the Armed Forces Institute of Pathology, the USDA ARS Southeast Poultry Research Laboratory, and Mount Sinai School of Medicine in New York City. The effort resulted in the announcement (on 5 October 2005) that the group had successfully determined the virus's genetic sequence, using historic tissue samples recovered by pathologist Johan Hultin from an Inuit female flu victim buried in the Alaskan permafrost and samples preserved from American soldiers[133] Roscoe Vaughan and James Downs.[134][135]

On 18 January 2007, Kobasa et al. (2007) reported that monkeys (Macaca fascicularis) infected with the recreated flu strain exhibited classic symptoms of the 1918 pandemic, and died from cytokine storms – an overreaction of the immune system. This may explain why the 1918 flu had its surprising effect on younger, healthier people, as a person with a stronger immune system would potentially have a stronger overreaction.[137]

On 16 September 2008, the body of British politician and diplomat Sir Mark Sykes was exhumed to study the RNA of the flu virus in efforts to understand the genetic structure of modern H5N1 bird flu. Sykes had been buried in 1919 in a lead coffin which scientists hoped had helped preserve the virus.[138] The coffin was found to be split and the cadaver badly decomposed; nonetheless, samples of lung and brain tissue were taken.[139]

In December 2008, research by Yoshihiro Kawaoka of the University of Wisconsin linked the presence of three specific genes (termed PA, PB1, and PB2) and a nucleoprotein derived from 1918 flu samples to the ability of the flu virus to invade the lungs and cause pneumonia. The combination triggered similar symptoms in animal testing.

In June 2010, a team at the Mount Sinai School of Medicine reported the 2009 flu pandemic vaccine provided some cross-protection against the 1918 flu pandemic strain.

One of the few things known for certain about the influenza in 1918 and for some years after was that it was, out of the laboratory, exclusively a disease of human beings.

In 2013, the AIR Worldwide Research and Modeling Group "characterized the historic 1918 pandemic and estimated the effects of a similar pandemic occurring today using the AIR Pandemic Flu Model". In the model, "a modern day 'Spanish flu' event would result in additional life insurance losses of between US$15.3–27.8 billion in the United States alone", with 188,000–337,000 deaths in the United States.

In 2018, Michael Worobey, an evolutionary biology professor at the University of Arizona who is examining the history of the 1918 pandemic, revealed that he obtained tissue slides created by William Rolland, a physician who reported on a respiratory illness likely to be the virus while a pathologist in the British military during World War One.[144] Rolland had authored an article in the Lancet during 1917 about a respiratory illness outbreak beginning in 1916 in Étaples, France.[145][146] Worobey traced recent references to that article to family members who had retained slides that Rolland had prepared during that time. Worobey extracted tissue from the slides to potentially reveal more about the origin of the pathogen.

See also

References

Citations

  1. ^ More modern terms for this event include the "1918 influenza pandemic," the "1918 flu pandemic," or variations of those. See, for instance: "Pandemic influenza: an evolving challenge". World Health Organization. 22 May 2018. Archived from the original on 20 March 2020 . Retrieved 20 March 2020 . "Influenza pandemic of 1918–19". Encyclopaedia Britannica. 4 March 2020. Archived from the original on 20 March 2020 . Retrieved 20 March 2020 . Chodosh, Sara (18 March 2020). "What the 1918 flu pandemic can teach us about COVID-19, in four charts". PopSci . Retrieved 20 March 2020 .
  2. ^ "Why COVID-19 is not like Spanish flu".
  3. ^ a b P. Spreeuwenberg; et al. (1 December 2018). "Reassessing the Global Mortality Burden of the 1918 Influenza Pandemic". American Journal of Epidemiology. 187 (12): 2561–2567. doi:10.1093/aje/kwy191. PMID 30202996.
  4. ^ "Ten things you need to know about pandemic influenza (update of 14 October 2005)" (PDF) . Weekly Epidemiological Record (Relevé Épidémiologique Hebdomadaire). 80 (49–50): 428–431. 9 December 2005. PMID 16372665.
  5. ^ Jilani, TN; Jamil, RT; Siddiqui, AH (14 December 2019). "H1N1 Influenza (Swine Flu)". PMID 30020613. Archived from the original on 12 March 2020 . Retrieved 11 March 2020 .
  6. ^ Anderson, Susan (29 August 2006). "Analysis of Spanish flu cases in 1918–1920 suggests transfusions might help in bird flu pandemic". American College of Physicians. Archived from the original on 25 November 2011 . Retrieved 2 October 2011 .
  7. ^ Gagnon A, Miller MS, Hallman SA, Bourbeau R, Herring DA, Earn DJ, Madrenas J (2013). "Age-specific mortality during the 1918 influenza pandemic: Unravelling the mystery of high young adult mortality". PLOS One. 8 (8): e69586. Bibcode:2013PLoSO...869586G. doi:10.1371/journal.pone.0069586 . PMC 3734171 . PMID 23940526.
  8. ^ MacCallum, W.G. (1919). "Pathology of the pneumonia following influenza". JAMA: The Journal of the American Medical Association. 72 (10): 720–723. doi:10.1001/jama.1919.02610100028012. Archived from the original on 25 January 2020 . Retrieved 16 August 2019 .
  9. ^ Hirsch, Edwin F.; McKinney, Marion (1919). "An epidemic of pneumococcus broncho-pneumonia". Journal of Infectious Diseases. 24 (6): 594–617. doi:10.1093/infdis/24.6.594. JSTOR 30080493.
  10. ^ Brundage JF, Shanks GD (December 2007). "What really happened during the 1918 influenza pandemic? The importance of bacterial secondary infections". The Journal of Infectious Diseases. 196 (11): 1717–1718, author reply 1718–1719. doi:10.1086/522355. PMID 18008258.
  11. ^ Morens DM, Fauci AS (April 2007). "The 1918 influenza pandemic: Insights for the 21st century". The Journal of Infectious Diseases. 195 (7): 1018–1028. doi:10.1086/511989. PMID 17330793.
  12. ^ "La Grippe Espagnole de 1918" (in French). Institut Pasteur. Archived from the original (Powerpoint) on 17 November 2015. (also here, requires Flash player)
  13. ^ "EU Research Profile on Dr. John Oxford". Archived from the original on 12 May 2009 . Retrieved 9 May 2009 .
  14. ^ Connor, Steve (8 January 2000). "Flu epidemic traced to Great War transit camp". The Guardian. UK. Archived from the original on 12 May 2009 . Retrieved 9 May 2009 .
  15. ^ Oxford JS, Lambkin R, Sefton A, Daniels R, Elliot A, Brown R, Gill D (January 2005). "A hypothesis: The conjunction of soldiers, gas, pigs, ducks, geese, and horses in northern France during the Great War provided the conditions for the emergence of the "Spanish" influenza pandemic of 1918–1919" (PDF) . Vaccine. 23 (7): 940–945. doi:10.1016/j.vaccine.2004.06.035. PMID 15603896. Archived (PDF) from the original on 12 March 2020 . Retrieved 12 March 2020 .
  16. ^ a b c Shanks GD (January 2016). "No evidence of 1918 influenza pandemic origin in Chinese laborers/soldiers in France". Journal of the Chinese Medical Association. 79 (1): 46–48. doi:10.1016/j.jcma.2015.08.009. PMID 26542935.
  17. ^ a b Michael Worobey, Jim Cox, Douglas Gill, The origins of the great pandemic, Evolution, Medicine, and Public Health, Volume 2019, Issue 1, 2019, Pages 18–25
  18. ^ a b Killingray, David; Phillips, Howard (2003). The Spanish Influenza Pandemic of 1918–1919: New Perspectives. Routledge. ISBN 978-1-134-56640-2.
  19. ^ a b c Langford, Christopher (2005). "Did the 1918-19 Influenza Pandemic Originate in China?". Population and Development Review. Vol. 31, No. 3 (Sep., 2005) (3): 473–505. doi:10.1111/j.1728-4457.2005.00080.x. JSTOR 3401475.
  20. ^ Cheng, K.F. "What happened in China during the 1918 influenza pandemic?". International Journal of Infectious Diseases. Volume 11, Issue 4, July 2007: 360–364. Archived from the original on 5 December 2019 . Retrieved 5 March 2020 .
  21. ^ a b Cheng, K.F. "What happened in China during the 1918 influenza pandemic?". International Journal of Infectious Diseases. Volume 11, Issue 4, July 2007: 360–364. Archived from the original on 5 December 2019 . Retrieved 5 March 2020 .
  22. ^ Klein, Christopher. "China Epicenter of 1918 Flu Pandemic, Historian Says". Archived from the original on 5 March 2020 . Retrieved 5 March 2020 .
  23. ^ Vergano, Dan. "1918 Flu Pandemic That Killed 50 Million Originated in China, Historians Say". National Geographic. Archived from the original on 3 March 2020 . Retrieved 5 March 2020 .
  24. ^ a b Saunders-Hastings, Patrick R.; Krewski, Daniel (6 December 2016). "Reviewing the History of Pandemic Influenza: Understanding Patterns of Emergence and Transmission". Pathogens. 5 (4): 66. doi:10.3390/pathogens5040066. ISSN 2076-0817. PMC 5198166 . PMID 27929449.
  25. ^ a b Hannoun, Claude (1993). "La Grippe". Documents de la Conférence de l'Institut Pasteur. La Grippe Espagnole de 1918. Ed Techniques Encyclopédie Médico-Chirurgicale (EMC), Maladies infectieuses. 8-069-A-10.
  26. ^ Vergano, Dan (24 January 2014). "1918 Flu Pandemic That Killed 50 Million Originated in China, Historians Say". National Geographic. Archived from the original on 26 January 2014 . Retrieved 4 November 2016 .
  27. ^ Sherman IW (2007). Twelve diseases that changed our world . Washington, DC: ASM Press. p. 161. ISBN 978-1-55581-466-3.
  28. ^ a b "Spanish flu strikes during World War I". 14 January 2010. Archived from the original on 11 December 2013.
  29. ^ Illing, Sean (20 March 2020). "The most important lesson of the 1918 influenza pandemic: Tell the damn truth". Vox. Archived from the original on 25 March 2020. John M. Barry : The government lied. They lied about everything. We were at war and they lied because they didn’t want to upend the war effort. You had public health leaders telling people this was just the ordinary flu by another name. They simply didn’t tell the people the truth about what was happening.
  30. ^ Barry JM (January 2004). "The site of origin of the 1918 influenza pandemic and its public health implications". Journal of Translational Medicine. 2 (1): 3. doi:10.1186/1479-5876-2-3. PMC 340389 . PMID 14733617.
  31. ^ Bynum B (14 March 2009). "Stories of an influenza pandemic" (PDF) . The Lancet. 373 (9667): 885–886. doi:10.1016/s0140-6736(09)60530-4. Archived (PDF) from the original on 7 March 2020 . Retrieved 4 March 2018 .
  32. ^ Rego Barry, Rebecca (13 November 2018). "Exhuming the Flu". Distillations. Science History Institute. 4 (3): 40–43. Archived from the original on 6 February 2020 . Retrieved 6 February 2020 .
  33. ^ "1918 Flu (Spanish flu epidemic)". Avian Bird Flu. Archived from the original on 21 May 2008.
  34. ^ Byerly CR (April 2010). "The U.S. military and the influenza pandemic of 1918-1919". Public Health Rep. 125 Suppl 3: 82–91. PMC 2862337 . PMID 20568570.
  35. ^ "Spanish flu facts". Channel 4 News. Archived from the original on 27 January 2010.
  36. ^ Siddharth Chandra and Julia Christensen (2 March 2019). "Re: "reassessing the Global Mortality Burden of the 1918 Influenza Pandemic " ". Am. J. Epid. 188 (7): 1404–1406. doi:10.1093/aje/kwz044. PMID 30824934. and response Peter Spreeuwenberg, Madelon Kroneman, and John Paget (2 March 2019). "The Authors Reply" (PDF) . Am. J. Epid. 188 (7): 1405–1406. doi:10.1093/aje/kwz041. PMID 30824908. Archived (PDF) from the original on 12 March 2020 . Retrieved 12 March 2020 . CS1 maint: multiple names: authors list (link)
  37. ^ "Historical Estimates of World Population". Archived from the original on 9 July 2012 . Retrieved 29 March 2013 .
  38. ^ Robinson Meyer (29 April 2016). "Human extinction isn't that unlikely". The Atlantic. Archived from the original on 1 May 2016 . Retrieved 6 February 2018 .
  39. ^ Mayor, S. (2000). "Flu experts warn of need for pandemic plans". British Medical Journal. 321 (7265): 852. doi:10.1136/bmj.321.7265.852. PMC 1118673 . PMID 11021855.
  40. ^ Chandra, Kuljanin & Wray 2012.
  41. ^ David Arnold, "Dearth and the Modern Empire: The 1918–19 Influenza Epidemic in India," Transactions of the Royal Historical Society 29 (2019): 181-200.
  42. ^ a b Iijima, W. (2003). "Spanish influenza in China, 1918–1920: a preliminary probe". In Phillips, H.; Killingray, D. (eds.). The Spanish Flu Pandemic of 1918: New Perspectives. London and New York: Routledge. pp. 101–109.
  43. ^ Iijima, Wataru (1998). The Spanish influenza in China, 1918–1920. OCLC 46987588.
  44. ^ Langford, Christopher (2005). "Did the 1918–19 Influenza Pandemic Originate in China?". Population and Development Review. 31 (3): 473–505. doi:10.1111/j.1728-4457.2005.00080.x. ISSN 1728-4457.
  45. ^ Iijima, Wataru (1998). "The Spanish influenza in China, 1918-1920".
  46. ^ Killingray, David; Phillips, Howard (2003). The Spanish Influenza Pandemic of 1918–1919: New Perspectives. Routledge. ISBN 978-1-134-56640-2.
  47. ^ a b c Spinney, Laura (2017). Pale rider – The Spanish flu of 1918 and how it changed the world. pp. 167–169. ISBN 978-1-910702-37-6.
  48. ^ "Spanish Influenza in Japanese Armed Forces, 1918–1920". Centers for Disease Control and Prevention (CDC).
  49. ^ Historical research report from University of Indonesia, School of History, as reported in Emmy Fitri. Looking Through Indonesia's History For Answers to Swine Flu Archived 2 November 2009 at the Wayback Machine. The Jakarta Globe. 28 October 2009 edition.
  50. ^ "1918 flu centenary: How to survive a pandemic". Archived from the original on 9 July 2019 . Retrieved 19 June 2019 .
  51. ^ Rice, Geoffrey; Bryder, Linda. Black November: the 1918 influenza pandemic in New Zealand (Second, revised and enlarged ed.). Christchurch, N.Z. ISBN 978-1927145913. OCLC 960210402.
  52. ^ The Great Pandemic: The United States in 1918–1919, U.S. Department of Health & Human Services.
  53. ^ "Flu Epidemic Hit Utah Hard in 1918, 1919". 28 March 1995. Archived from the original on 30 November 2012 . Retrieved 7 July 2012 .
  54. ^ "The Great Pandemic of 1918: State by State". 5 March 2018. Archived from the original on 6 May 2009 . Retrieved 4 May 2009 .
  55. ^ "A deadly virus rages throughout Canada at the end of the First World War". CBC History.
  56. ^ "A gripe espanhola no Brasil – Elísio Augusto de Medeiros e Silva, empresário, escritor e membro da AEILIJ" (in Portuguese). Jornal de Hoje. Archived from the original on 2 February 2014 . Retrieved 22 January 2014 .
  57. ^ "The "bird flu" that killed 40 million". BBC News. 19 October 2005. Archived from the original on 7 November 2017 . Retrieved 26 April 2009 .
  58. ^ Marcus, Harold (1996). Haile Sellassie I: The formative years, 1892–1936. Trenton, NJ: Red Sea Press. pp. 36ff.
  59. ^ Morris, Denise E.; Cleary, David W.; Clarke, Stuart C. (2017). "Secondary Bacterial Infections Associated with Influenza Pandemics". Frontiers in Microbiology. 8. doi:10.3389/fmicb.2017.01041. ISSN 1664-302X.
  60. ^ "Bacterial Pneumonia Caused Most Deaths in 1918 Influenza Pandemic". National Institutes of Health. 23 September 2015. Archived from the original on 22 April 2016 . Retrieved 17 April 2016 .
  61. ^ Hanssen, Olav. Undersøkelser over influenzaens optræden specielt i Bergen 1918–1922. Bg. 1923. 66 s. ill. (Haukeland sykehus. Med. avd. Arb. 2) (Klaus Hanssens fond. Skr. 3)
  62. ^ Payne MS, Bayatibojakhi S (2014). "Exploring preterm birth as a polymicrobial disease: an overview of the uterine microbiome". Frontiers in Immunology. 5: 595. doi:10.3389/fimmu.2014.00595. PMC 4245917 . PMID 25505898.
  63. ^ "Key Facts about Swine Influenza". Archived from the original on 4 May 2009 . Retrieved 30 April 2009 .
  64. ^ "1918 Death Certificate for 10-year-old girl who died as a consequence of influenza in Lares, Puerto Rico".
  65. ^ Pandemic Influenza (PDF) . Science and Technology Committee (Report). Report of Session 2005–2006. 4th. Broers, Alec, Baron Broers (chairman). UK House of Lords. 16 December 2005. HL Paper 88. Archived from the original (PDF) on 8 May 2009 . Retrieved 6 May 2009 . CS1 maint: others (link)
  66. ^ Influenza 1918 episode (documentary). American Experience. PBS. [full citation needed ]
  67. ^ Fogarty International Center. "Summer Flu Outbreak of 1918 May Have Provided Partial Protection Against Lethal Fall Pandemic". Fic.nih.gov. Archived from the original on 27 July 2011 . Retrieved 19 May 2012 .
  68. ^ "Viruses of mass destruction". cnn.com. Fortune. 1 November 2004. Archived from the original on 6 May 2009 . Retrieved 30 April 2009 .
  69. ^ a b Wishart, Skye (July–August 2018). "How the 1918 flu spread". New Zealand Geographic (152): 23. Archived from the original on 3 August 2018 . Retrieved 3 August 2018 .
  70. ^ Langford, Christopher (2005). "Did the 1918–19 Influenza Pandemic Originate in China?". Population and Development Review. 31 (3): 473–505. doi:10.1111/j.1728-4457.2005.00080.x. ISSN 0098-7921. JSTOR 3401475.
  71. ^ Cheng, K. F.; Leung, P. C. (1 July 2007). "What happened in China during the 1918 influenza pandemic?". International Journal of Infectious Diseases. 11 (4): 360–364. doi:10.1016/j.ijid.2006.07.009. ISSN 1201-9712. PMID 17379558.
  72. ^ Killingray, David; Phillips, Howard (2003). The Spanish Influenza Pandemic of 1918–1919: New Perspectives. Routledge. ISBN 978-1-134-56640-2.
  73. ^ Killingray, David; Phillips, Howard (2003). The Spanish Influenza Pandemic of 1918-1919: New Perspectives. Routledge. ISBN 978-1-134-56640-2.
  74. ^ a b c d e f Killingray, David; Phillips, Howard (2003). The Spanish Influenza Pandemic of 1918–1919: New Perspectives. Routledge. ISBN 978-1-134-56640-2.
  75. ^ Langford, Christopher (2005). "Did the 1918–19 Influenza Pandemic Originate in China?". Population and Development Review. 31 (3): 473–505. doi:10.1111/j.1728-4457.2005.00080.x. ISSN 1728-4457.
  76. ^ "Influenza of 1918 (Spanish Flu) and the US Navy". history.navy.mil. Archived from the original on 11 January 2015 . Retrieved 14 May 2009 .
  77. ^ World Health Organization Writing Group (2006). "Nonpharmaceutical interventions for pandemic influenza, international measures". Centers for Disease Control and Prevention (CDC) Emerging Infectious Diseases (EID) Journal. 12 (1): 81–87. doi:10.3201/eid1201.051370. PMC 3291414 . PMID 16494722.
  78. ^ "1919 – Spanish Flu Reports in south-western Victoria, Australia". 17 September 2004. Archived from the original on 17 September 2004.
  79. ^ Ryan, Jeffrey, ed. (2009). Pandemic Influenza: Emergency planning and community preparedness. Boca Raton, FL: CRC Press. p. 24.
  80. ^ "Colonial Annual Report", 1919
  81. ^ Almond, Douglas (1 August 2006). "Is the 1918 Influenza Pandemic Over? Long‐Term Effects of In Utero Influenza Exposure in the Post‐1940 U.S. Population". Journal of Political Economy. 114 (4): 672–712. doi:10.1086/507154. ISSN 0022-3808.
  82. ^ Beach, Brian; Ferrie, Joseph P.; Saavedra, Martin H. (2018). "Fetal shock or selection? The 1918 influenza pandemic and human capital development". nber.org. doi:10.3386/w24725. Archived from the original on 18 June 2018 . Retrieved 18 June 2018 .
  83. ^ Lindley, Robin. "The Forgotten American Pandemic: Historian Dr. Nancy K. Bristow on the Influenza Epidemic of 1918". hnn.us. Archived from the original on 8 August 2014 . Retrieved 4 August 2014 .
  84. ^ "Open Collections Program: Contagion, Spanish Influenza in North America, 1918–1919". Archived from the original on 20 November 2016 . Retrieved 22 November 2016 .
  85. ^ Harder, Timm C.; Ortrud, Werner. "Chapter Two: Avian Influenza". Influenza Report 2006. published online. Sometimes a virus contains both avian-adapted genes and human-adapted genes. Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005).
  86. ^ "Researchers reconstruct 1918 pandemic influenza virus; effort designed to advance preparedness". Center for Disease Control. Archived from the original on 19 October 2011 . Retrieved 2 September 2009 .
  87. ^ "CLOSING IN ON A KILLER: SCIENTISTS UNLOCK CLUES TO THE SPANISH INFLUENZA VIRUS". National Museum of Health and Medicine . Retrieved 23 March 2020 .
  88. ^ Kolata, Gina (16 February 1999). "Scientists Uncover Clues To Flu Epidemic of 1918". The New York Times . Retrieved 23 March 2020 .
  89. ^ "Research on monkeys finds resurrected 1918 flu killed by turning the body against itself". USA Today. Archived from the original on 5 March 2009 . Retrieved 14 August 2008 .
  90. ^ "Body exhumed in fight against flu". BBC News. Archived from the original on 17 September 2008 . Retrieved 16 September 2008 .
  91. ^ In Search of Spanish Flu (documentary). BBC Four.
  92. ^ Branswell, Helen (5 December 2018). "A shot-in-the-dark e-mail leads to a century-old family treasure – and hope of cracking a deadly flu's secret". Stat. Archived from the original on 5 December 2018 . Retrieved 5 December 2018 .
  93. ^ Hammond, J.A.B.; Rolland, William; Shore, T.H.G. (14 July 1917). "Purulent bronchitis: A study of cases occurring amongst the British troops at a base in France". The Lancet. 190 (4898): 41–45. doi:10.1016/S0140-6736(01)56229-7. PDF version here Archived 26 August 2019 at the Wayback Machine
  94. ^ "The Influenza Pandemic of 1918". World War 1 Centenary. Oxford, England: University of Oxford. Archived from the original on 9 December 2018 . Retrieved 8 December 2018 .

Bibliography

Further reading

External links

https://en.wikipedia.org/wiki/Spanish_flu