MERS-CoV spike protein: Targets for vaccines and therapeutics - ScienceDirect

Highlights

A licensed vaccine or therapeutic against MERS-CoV remains unavailable to date.

The S protein plays a pivotal role for virus entry and thus is an ideal target for vaccine and antiviral development.

DNA vaccines expressing the S protein merit further development for potential human application.

nAbs and peptides targeting the S protein needs to be evaluated in NHPs before clinical trials.

Abstract

The disease outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) is still ongoing in the Middle East. Over 1700 people have been infected since it was first reported in September 2012. Despite great efforts, licensed vaccines or therapeutics against MERS-CoV remain unavailable. The MERS-CoV spike (S) protein is an important viral antigen known to mediate host-receptor binding and virus entry, as well as induce robust humoral and cell-mediated responses in humans during infection. In this review, we highlight the importance of the S protein in the MERS-CoV life cycle, summarize recent advances in the development of vaccines and therapeutics based on the S protein, and discuss strategies that can be explored to develop new medical countermeasures against MERS-CoV.

Keywords

Coronavirus

MERS-CoV

Spike protein

Vaccines

Therapeutics

Animal models

View Abstract

© 2016 Elsevier B.V. All rights reserved.

https://www.sciencedirect.com/science/article/pii/S0166354216301826