ACTIV | National Institutes of Health (NIH)

Overview

On April 17, 2020 the National Institutes of Health (NIH) announced the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership to develop a coordinated research strategy for prioritizing and speeding development of the most promising treatments and vaccines.

Coordinated by the Foundation for the National Institutes of Health (FNIH), ACTIV brings NIH together with its sibling agencies in the Department of Health and Human Services, including the Biomedical Advanced Research and Development Authority (BARDA), Centers for Disease Control and Prevention (CDC), and the U.S. Food and Drug Administration (FDA); other government agencies including the Department of Defense (DOD) and Department of Veterans Affairs (VA); the European Medicines Agency (EMA); and representatives from academia, philanthropic organizations, and numerous biopharmaceutical companies.

Challenge

The COVID-19 pandemic is an unprecedented global crisis that has been met with a swift and extraordinary response. Since the novel coronavirus was first reported in late 2019, institutions and organizations around the world have launched hundreds of research studies on diagnosis, prevention, and treatment strategies—all of which are critical to the world’s ability to return to normal.

With limited resources, there is a need to coordinate and streamline processes to make the best use of biomedical research resources and testing of preclinical compounds.

The research community is sifting through more than 100 potential preventives and treatments. However, because so many studies are recruiting patients, many of those studies could fail to enroll enough participants to answer their research questions. In addition, lack of coordination could make interpretation and comparison of the results difficult. Meanwhile, healthcare providers on the front lines are taking care of critically ill patients every day. They need solid information grounded in research.

With limited resources, there is a need to coordinate and streamline processes to make the best use of biomedical research resources and testing of preclinical compounds. There is also a need to prioritize the most promising vaccine candidates and move them into clinical trials in a way that is safe and efficient.

Opportunity

Through the ACTIV initiative, NIH is pursuing four fast-track focus areas most ripe for opportunity, each of which is led by a working group of senior scientists representing government, industry, non-profit, philanthropic, and academic organizations.

Fast Track Area #1

Develop a collaborative, streamlined forum to identify preclinical treatments.

How we plan to accomplish this:

Fast Track Area #2

Accelerate clinical testing of the most promising vaccines and treatments.

How we plan to accomplish this:

Fast Track Area #3

Improve clinical trial capacity and effectiveness.

How we plan to accomplish this:

Fast Track Area #4

Accelerate the evaluation of vaccine candidates to enable rapid authorization or approval.

How we plan to accomplish this:

Leadership Organizations

Through ACTIV, NIH brings together government agencies, nonprofit organizations, and numerous biopharmaceutical companies.

Government

Industry

Non-Profit

Organization Chart

Download the PDF

https://www.nih.gov/research-training/medical-research-initiatives/activ